Viral Replication Protein Inhibits Cellular Cofilin Actin Depolymerization Factor to Regulate the Actin Network and Promote Viral Replicase Assembly.

RNA viruses exploit host cells Chop Saw by co-opting host factors and lipids and escaping host antiviral responses.Previous genome-wide screens with Tomato bushy stunt virus (TBSV) in the model host yeast have identified 18 cellular genes that are part of the actin network.In this paper, we show that the p33 viral replication factor interacts with

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Immunogenicity of a virosomally-formulated Plasmodium falciparum GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to adjuvanted formulations

Abstract Background In clinical trials, immunopotentiating reconstituted influenza virosomes (IRIVs) have shown great potential as a versatile antigen delivery platform for synthetic peptides derived from Plasmodium falciparum antigens.This study describes the immunogenicity of a virosomally-formulated recombinant fusion protein comprising domains

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Analysis of metabolic differences between Jiaosu fermented from dendrobium flowers and stems based on untargeted metabolomics

Dendrobium officinale is an important traditional Chinese medicinal herb Medical Tests containing bioactive polysaccharides and alkaloids.This study characterized metabolite differences between jiaosu (fermented plant product) from Dendrobium flowers versus stems using untargeted metabolomics.The jiaosu was fermented by mixed fermentation of Saccha

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Casting the Net Widely for Change in Animal Welfare: The Plight of Birds in Zoos, Ex Situ Conservation, and Conservation Fieldwork

This paper discusses paradoxes in our relationship to and treatment of birds in captive and conservation contexts.The paper identifies modern and new challenges that arise from declining bird numbers worldwide.Such challenges have partly changed zoos Jewelry into providers of insurance populations specifically for species at risk of extinction.They

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